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Marshall U researchers get patent for new sepsis treatment

Researchers at Marshall University have been awarded a U.S. patent for a new method for treating sepsis. The Marshall TTO is seeking a licensee for the patented technology.

Researchers developed the method for treating sepsis and other inflammatory disorders using cerium oxide nanoparticles. Eric Blough, PhD, professor in the School of Pharmacy, said the novel method of cerium oxide nanoparticles application opens new doors to treat sepsis and other disorders including alcoholic liver disease and the inflammation seen after trauma, severe burns or spinal injury.

“Sepsis is a serious complication caused by the body’s overwhelming response to infection, which can lead to tissue damage, multi-organ failure and death,” Blough said. “Current treatment strategies, which include the use of antibiotics, fluid resuscitation and additional support based on the symptoms, fail to address the needs of patients adequately. With the increase in antibiotic resistance and emergence of multidrug resistant pathogens, current treatment modalities are increasingly being challenged. Our method for treating sepsis using cerium oxide nanoparticles addresses this aptly without any potential concern for antibacterial resistance.”

Nandini D.P.K. Manne, PhD, a researcher at Marshall’s Center for Diagnostic Nanosystems and lead author on several of the publications generated from the research, said “our method shows that nanoparticles can be used to treat sepsis effectively. One major advantage is the lack of necessity for any refrigeration and long shelf life, which suggests that cerium oxide nanoparticles may be ideal for treating sepsis in resource-poor environments where proper medical and storage facilities are totally lacking. The biological applications of cerium oxide nanoparticles are enormous and could be used to address many unmet medical needs.”

The treatment involves the nanoparticles being injected into a vein, after which they passively target liver Kupffer cells and exert the beneficial effects. Cerium oxide is already widely used as a polishing agent for glass mirrors, in sunscreens, ophthalmic lenses and in the automobile industry to increase fuel efficiency.

Source: The Herald-Dispatch

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