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Purdue researchers develop a new and improved rescue kit for people with diabetes

By Jesse Schwartz
Published: November 7th, 2018

Researchers at Purdue University are developing a new rescue kit for people with diabetes.

Purdue professor Elizabeth Topp is leading a research team to improve on common EpiPen-like devices for diabetic patients and others with hypoglycemia. Topp says she was partly inspired by a young student volleyball player she knew with diabetes who needed a nurse to travel with her to games in case she needed an injection of glucagon to raise her sugar levels.

“Our technology will hopefully one day be able to help that student and millions of other people and their families impacted by hypoglycemia,” says Topp. “We want an easier alternative to the current rescue kits that require someone to mix components and then figure out how to properly inject the glucagon.”

The Purdue researchers addressed glucagon’s poor solubility by using peptide derivatives of glucagon, which have shown to be soluble and stable in solution. The derivatives are quickly re-converted to glucagon after injection by enzymes in the body, creating an easier and quicker alternative to delivering glucagon to someone in need.

Topp is now working with the Purdue Office of Technology Commercialization and Monon Bioventures to take her research team’s innovation to market.

“It’s incredible to think that four researchers from places all across the globe were able to come together for this potentially life-changing discovery,” Topp says. “Purdue is a place that makes such collaboration possible.”

Source: Purdue Research Foundation News

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